Harry Olverman


Dr. Henry Olverman
Senior Lecturer
Tel: +44(0) 131 650 3523



Lab Webpage

E-mail: H.Olverman@ed.ac.uk

Research Interests
A key objective of the current research programme, conducted jointly with Paul Kelly, is to search for new molecular targets in human mood disorders using a genomic, neurobiological and systems approach in animal models.  We focus on human depressive disorders for which we can identify molecular mechanisms aimed at developing novel therapeutic strategies. We are currently testing the hypothesis that a history of exposure to MDMA in females may, by altering their stress responses during pregnancy, impinge upon the future physical and mental health of offspring. In addition we are investigating the physiological, neurochemical, electrophysiological, endocrinological and behavioural effects in transgenic mice where the expression of SERT has been altered in order to further explore the involvement of the serotonergic system in the aetiology of clinical depression.

Key Publications
Dawson, N, Ferrington, L, Olverman, HJ, and Kelly, PAT. (2008)  Novel analysis for improved validity in semi-quantitative 2-deoxyglucose autoradiographic imaging.  J. Neurosci. Methods 175, 25-35.
Jennings, KA, Loder, MK, Sheward, J, Pei, Q, Deacon, RMJ, Benson, MA, Olverman, HJ, Hastie, ND, Harmar, AJ, Shen, S, and Sharp, T. (2006)  Increased expression of the 5-HT transporter confers a low anxiety phenotype linked to decreased 5-HT transmission.  J. Neurosci. 26, 8955-8964.
Dawson, N, Ferrington, L, Olverman, HJ, Harmar, AJ and Kelly, PAT. (2009)  Gender influences the effect of a life-long increase in serotonin transporter function on cerebral metabolism.  J. Neurosci. Res. 87, 2375-2385.
Neufeld-Cohen, A, Kelly, PAT, Paul, EE, Skinner, E, Olverman, HJ, Vaughan, JM, Issler, O, Lowry, CA, Vale, WW, Seckl, JR, Chen, A and Jamieson, PM. (2012)  Chronic activation of CRF type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and 5-HT responses to stressful challenge.  Biol. Psychiatry, 72, 437-447.
Issler, O, Carter, RN, Paul, ED, Kelly, PAT, Olverman, HJ, Lowry, CA, Seckl, JR, Chen, A and Jamieson, PM. (2014)  The role of the CRF receptor type 2 in stress recovery is mediated via modulation of serotonergic circuits in the lateral septum and subiculum. Biology of Mood & Anxiety Disorders 4, 1.

Funding Sources
European Commission Research Directorates, Research & Technological Development Project, 6th Framework Programme

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