Iris Oren

Techniques
Slice electrophysiology (patch, clamp, field);
Optogenetics;
In vivo EEG recordings;
Immunohistochemistry

Lab Members
Dr Rosalind Brown (Post-doc)
Keir Shaffick-Richardson (PhD student)

 

Dr. Iris Oren
Lecturer and Chancellor's Fellow
Tel: +44(0) 131 651 1903

 

 

Lab Webpage

E-mail: Iris.Oren@ed.ac.uk

Research Interests
The brain's computational circuits are made up of specialised neuronal subtypes. In particular, different types of inhibitory neurons control or modulate the activity of other neurons, and so perform different operations on the information that propagates through the circuits. My laboratory is interested in how circuits in the brain's memory regions (particularly, the hippocampus) perform computations, and how changes to different cell types can alter circuit function in diseases that affect memory, such as Alzheimer's disease.

Key Publications
Zemankovics R, Veres J, Oren I and Hájos N. (2013) Feedforward inhibition underlies the propagation of cholinergically induced gamma oscillations from hippocampal CA3 to CA1. J Neurosci 22: 12337-51.
Akam T, Oren I, Mantoan L, Ferenczi E and Kullmann DM. (2012). Oscillatory dynamics in the hippocampus support dentate gyrus CA3 coupling. Nat Neurosci 15: 763-8.
Oren I, Hájos N and Paulson O. (2010) Identification of the current generator underlying cholinergically induced gamma frequency field potential oscillations in the hippocampal CA3 region. J Physiol 588: 785-97.
Oren I, Nissen W, Kullmann D, Somogyi P and Lamsa K. (2009) Role of ionotropic glutamate receptors in LTP in rat hippocampal CA1 oriens-lacunosum moleculare interneurons. J Neurosci 29: 939-50.
Oren I, Mann EO, Paulsen O and Hájos N. (2006) Synaptic currents in anatomically indentified CA3 neurons during hippocampal gamma oscilaltions in vitro. J Neurosci 26: 9923-34.

Funding Sources
Alzheimer's Research UK; Alzheimer's Society; Royal Society

Biography
You can access a short biography by clicking here.