Professor Jeremy Hall
Professor (Neuroscience and Mental Health Research Institute, Cardiff University)
Hon Professor (Division of Psychiatry, University of Edinburgh)

Tel: +44(0) 2920 688342

 

 

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E-mail: hallj10@cardiff.ac.uk

Research Interests
Translational studies of schizophrenia and autism
My overarching interest is in the role of genetic and environmental risk factors in the development of mental health disorders, especially schizophrenia and autism. In my work I employ a translational approach to study how genetic and environmental factors enhance risk for mental illness. I am particularly interested in how identified major risk factors affect associative learning processes in the brain, leading to the key symptoms seen in a range of mental health problems. My current work is focussed on a group of genes associated with risk for mental disorder which operate at synapses. We are actively investigating the expression and regulation of these genes and the effects of risk-associated variants on learning and cognitive function in both model systems and patients. Overall I believe that understanding of how genetic risk factors influence the brain and how these responses are modulated by environmental stimuli is crucial to the development of new treatments for psychiatric illness. In addition to my research work I also conduct clinical work in patients with schizophrenia and autism and I am the academic lead for the ABUHB Adult Neurodevelopmental Disorder Service and the Cardiff Adult Autism Service.

Key Publications
Brydges M, Seckl J, Torrance HS, Holmes MC, Evans KL and Hall J. (2014) Juvenile stress produces long-lasting changes in hippocampal DISC1, GSK3ß and NRG1 expression. Molecular Psychiatry, Epub.
Romaniuk L, Honey G, King JL, Whalley H, McIntosh AM, Levita L, Hughes M, Johnstone EC, Day M, Lawrie SM and Hall J. (2010) Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophrenia. Archives of General Psychiatry 67, 1246-1254.
Hall J, Romaniuk L, McIntosh AM, Steele JD, Johnstone EC and Lawrie SM. (2009) Associative learning and the genetics of schizophrenia. Trends in Neurosciences, 32, 359-365.
Hall J, Whalley HC, Job DE, Baig BJ, McIntosh AM, Evans KL, Thomson PA, Porteous DJ, Cunningham-Owens DG, Johnstone EC and Lawrie SM. (2006) A Neuregulin-1 variant associated with abnormal cortical function and psychotic symptoms. Nature Neuroscience 9, 1477-1478.
Hall J, Thomas KL and Everitt BJ. (2000)Rapid and selective induction of BDNF expression in the hippocampus during contextual learning. Nature Neuroscience 3, 533-5.