Paul Kelly

Lab Members

 

Dr. Paul A.T. Kelly,

 

 

Lab Webpage

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Research Interests
The overall aim of our work is to characterise the mechanisms by which both genetically-determined and environmentally-induced alterations in central neurotransmitter function in general, and monoaminergic function in particular, contributes to the aetiology of affective disorders. Specifically, our current objectives are:

    • To characterise brain function in animals that have been genetically modified to produce endophenotypes that paraellel psychiatric disorders in man.
    • To examine interactions between exposure to recreational drugs and genetic predisposition to psychiatric disorders.
    • To characterise brain function in animals where genetic modification alters central monoaminergic, either directly or indirectly.
    • To characterise the mechanisms by which altered cerebrovascular physiology might contribute to changes in brain function induced by both genetic and environmental manipulation of central monoaminergic systems.

Key Publications
Rutten, K, Van Donkelaar, El, Ferrington L, Bollen, E, Steinbusch, HWM, Blokland, A, Kelly PAT, and Prickaerts, JHHJ.  (2009) Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats.  Neuropsychopharmacol. 34, 1914-1925.
And
ó, RD, Ádori, C, Kirilly, E, Kovacs, GG, Ferrington, L, Kelly. PAT, and Bagdy, G.  (2010) Acute SSRI-induced anxiogenesis and brain metabolic effects are attenuated despite partial recovery of serotonergic terminals six months after initial MDMA-induced depletion.  Behav. Brain Res. 207, 280-289.
Dawson, N, Ferrington, L, Lesch, K-P and Kelly, PAT. (2011) Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European Neuropsychopharmacol. 21, 117 – 128.
Van Donkelaar, EL, Blokland, A, Ferrington, L, Kelly, PAT, Steinbusch, HWM and Prickaerts, J. (2011) Mechanism of acute tryptophan depletion: Beyond the serotonin system. Molecular Psychiatry 16, 695-713.
Neufeld-Cohen, A, Kelly, PAT, Paul, EE, Skinner, E, Olverman, HJ, Vaughan, JM, Issler, O, Lowry, CA, Vale, WW, Seckl, JR, Chen A, and Jamieson, PM. (2012) Chronic activation of CRF type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and 5-HT responses to stressful challenge. Biol. Psychiatry, 72, 437-447.