Matt Nolan


Dr Matt Nolan
School of Biomedical Sciences
Tel: +44(0) 131 650 9874





Research Interests
Synaptic and molecular mechanisms for computation of location
We are interested in molecular mechanisms that configure neural circuits to carry out computations. Our approach combines electrophysiological, molecular and behavioural analysis, with computational modeling and development of molecular and software tools. Current topics of interest include homeostatic control of neuronal activity in vivo, circuit mechanisms for encoding of location by the entorhinal cortex and hippocampus, and roles of ion channels in circuit computations important for motor behaviour. We hope that over the long term our research will be important for understanding and treating clinical disorders such as Alzheimer’s, schizophrenia, autism and epilepsy.

Key Publications
Pastoll H, Solanka L, van Rossum MCW and Nolan MF. (2013) Feedback inhibition enables theta-nested gamma oscillations and grid firing fields. Neuron 77, 141-154.
Zonta, B, Desmazieres, A, Rinaldi, A, Tait, S, Sherman, DL, Nolan, MF*, and Brophy, PJ.* (2011) A Critical Role for Neurofascin in Regulating Action Potential Initiation through Maintenance of the Axon Initial Segment. Neuron 69, 945-956. * Joint corresponding authors.
Cannon, RC, O’Donnell, C and Nolan, MF. (2010) Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes. PLoS Computational Biology 6(8): e1000886. doi:10.1371/journal.pcbi.1000886
Garden, DLF, Dodson , PD, O’Donnell, C, White, MD  and Nolan,  MF. (2008) Tuning of Synaptic Integration in the Medial Entorhinal Cortex to the Organization of Grid Cell Firing Fields. Neuron 60, 875-889.