Tomonori Takeuchi



 

Dr. Tomonori Takeuchi
Postdoctoral Associate
Morris Lab
Tel: +44(0) 131 650 4571

 


Lab Webpage


E-mail: Tomonori.Takeuchi@ed.ac.uk

Research Interests
The focus of my research is cellular and molecular mechanisms of rapid learning depending on both novelty and prior knowledge. Novelty activates neuromodulatory systems that innervate and drive dopamine receptors in the hippocampus. This modulates the initial memory consolidation in neurons and turns a short-term memory into a long-term memory. Concerning about prior knowledge, activated prior knowledge representing a schema can support rapid acquisition and assimilation of new information into this existing schema. I am attempting to elucidate the cellular and molecular mechanisms of rapid learning depending on both novelty and prior knowledge using combination of a behavioural task of event arena for both mice and rats, and neuropharmacological and molecular biological techniques.

Key Publications
Takeuchi, T, Duszkiewicz, AJ and Morris, RGM. (2014) The synaptic plasticity and memory hypothesis: encoding, storage and persistence. Phil. Trans. R. Soc. B, 20130288.
Morris, RGM and Takeuchi, T. (2012) The Imaginary mind of a mouse. Science, 335: 1455-1456.
Tse, D*, Takeuchi, T*, Kakeyama, M, Kajii, Y, Okuno, H, Tohyama, C, Bito, H and Morris, RGM. (2011) Schema-Dependent Gene Activation and Memory Encoding in Neocortex. Science, 333, 891–895. *These authors contributed equally to this work.
Uemura, T, Lee, SJ, Yasumura, M, Takeuchi, T, Yoshida, T, Ra, M, Taguchi, R, Sakimura, K and Mishina, M. (2010) Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell, 141: 1068–1079.
Takeuchi, T, Miyazaki, T, Watanabe, M, Mori, H, Sakimura, K and Mishina, M. (2005) Control of synaptic connection by glutamate receptor δ2 in the adult cerebellum. Journal of Neuroscience 25, 2146–2156.

Funding Sources
2012-present: The European Research Council
2011-2012: Medical Research Council
2010-2011: Mitsubishi Tanabe Pharma Corporation
2009-2010: Astellas Foundation for Research on Metabolic Disorders
2008-2009: The Uehara Memorial Foundation