Rosie Jackson


Rosie Jackson
PhD Student
Spires-Jones Lab
Tel: +44(0) 131 650 6940



Lab Webpage


Research Interests
The apolipoprotein E (APOE) ε4 allele is the most potent genetic risk factor for Alzheimer’s. Carriers of APOE ε4 are 12-times more likely to develop AD and after onset of the disease, cognitive decline is more rapid in those with an APOE ε4 allele. A decrease in synapse density is the strongest correlate to the loss of cognitive function associated with Alzheimer’s. Looking at the differences in protein levels in the synapse will hopefully enable us to learn more about why and how this synapse loss occurs in Alzheimer’s disease with a view to interrupt them. To study these protein changes a combination of techniques including proteomics and array tomography will be utilized to look at the changes that occur at the synapse in end-stage human tissue and animal models. 



Funding Sources
College of Medicine and Veterinary Medicine Studentship, and Edinburgh Global Research Scholarship, University of Edinburgh