Techniques

Array tomography
Biochemical assays
Behavioural testing
Electrophysiology (in vivo/vitro)
Functional and structural imaging (in vivo/vitro)
Optogenetics
Stereology

Patched cell and PSCs

Rig

Spires-Jones lab

Spinydendrite

Memory is made possible by the ability of synapses, the connections between neurons in the brain, to change in response to environmental inputs.  In neurodegenerative diseases including Alzheimer’s disease and other forms of dementia, memory declines because synapses and neurons become dysfunctional and die.  In fact, the severity of dementia in Alzheimer’s disease strongly corresponds to the extent of synapse loss in the patient’s brain.  

The PoM Group studies the pathological processes involved in dementia from the basic biological mechanisms through to investigation of translational pathways that could lead to therapeutics.  We bring together a combination of techniques that allows structural, molecular, and functional analyses of disease models and donated human brain tissue.  Oliver Hardt uses his expertise in forgetting and behavioural analyses of cognitive decline. Iris Oren uses electrophysiology and imaging to study the functional changes in memory circuits. Tara Spires-Jones uses advanced imaging techniques to study pathological progression and synaptic changes in the brain that are associated with dementia, and whether these changes are reversible with therapeutic interventions.

S-J